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Difficult behavior

Medications for autism in children: when they're prescribed and what they can't replace

AuthorMaksym Izmaylovmethodologist, co-founder of Sense Behavior
6 min readUpdated 2026-09-16

If a doctor has prescribed a child medication, or medications for autism have already been tried without a clear result, that's not a reason to feel guilty or a sign that something was done wrong. Medication is a separate, legitimate tool with a clear scope of use, and it helps to understand where that scope starts and where it ends.

What these medications actually treat

Only two medications are officially approved for children with autism: risperidone and aripiprazole, both antipsychotics. An important detail: they're approved not for "treating autism" as such, but specifically for irritability, a clinical term that covers severe outbursts of aggression, self-injurious behavior, and intense tantrums that put the child or others at risk. No medication today is approved for the core features of autism itself, how a child communicates and interacts with the world.

What a large review of research found

In 2023, a large Cochrane review pulled together data from 131 studies involving over 7,000 people (Iffland et al., 2023). It confirmed that these medications do reduce severe problem behavior in the short term, but come with real side effects, mainly drowsiness and weight gain, and there isn't yet enough data on what happens with long-term use.

The review emphasizes that the benefits and the risk of side effects should be weighed separately when prescribing these medications, rather than treating the decision as clear-cut (Iffland et al., 2023, Cochrane Database of Systematic Reviews).

Why behavioral therapy doesn't replace or cancel out medication

Medication and applied behavior analysis (ABA) solve different problems rather than competing with each other. A medication can reduce the intensity of an outburst right now, but it doesn't explain why it's happening or what to do so it happens less often. That's exactly what behavioral therapy works on: it helps identify the function of a behavior, what the child is trying to get or avoid by it, and teaches safer ways to get the same thing. Many families use both approaches at the same time, and there's no contradiction in that: one takes the edge off the moment, the other changes what happens over the long run.

What we offer

If behavioral outbursts are what you're dealing with right now, it helps to understand what's actually behind a specific behavior: Function of behavior: why a child does what they do. If it's specifically about tantrums, we have a separate guide: Tantrums in a child with autism: what to do in the moment.

You can start with a free thirty-minute consultation, where we'll talk through your specific situation and how behavioral work can complement treatment already in place.

Sources

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